1. oarsi_white_paper_oa_serious_disease_121416_1Osteoarthritis: A Serious Disease, Submitted to the U.S. Food and Drug Administration December 1, 2016
2. Understanding your Joint Pain: Know the Signs & Symptoms of Osteoarthritis – sourced https://oaaction. unc.edu/individuals/
3. ARC Journal of Anesthesiology Updates in Knee Joint Osteoarthritis Alaa Ali M. Elzohry MD*1 , Mohammed Farghaly Abd Elhamed MSc2 , Bahaa Gamal Saad MSc2
4. Mayo Clinic, Symptoms and causes of Osteoarthritis, sourced from – https://www.mayoclinic. org/diseases-conditions/osteoarthritis/symptoms-causes/syc-20351925?p=1
5. review-tga-transparency-1101-submission-arthritis-australia
6. SYMPTOMATIC EFFICACY OF AVOCADO/SOYBEAN UNSAPONIFIABLES IN THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE AND HIP A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial with a Six-Month Treatment Period and a Two-Month Followup Demonstrating a Persistent Effect EMMANUEL MAHEU et al
7. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial F.Blotman et al
8. APRÉSFLEX is a registered trademark of PLT/LailaNutra LLC. ® 2015 PLT Health Solutions. All rights reserved.
9. Efficacy and Safety of Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis of the Knee: A Short-Term 30-Day Randomized, Double-Blind, Placebo-Controlled Clinical Study Vasu Karlapudi et al
10. A Double Blind, Randomized, Placebo Controlled Clinical Study Evaluates the Early Efficacy of Aflapin® in Subjects with Osteoarthritis of Knee. Amar A. Vishal et al
11. Comparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study Krishanu Sengupta et al

Scheduling status: Proprietary name (and dosage form): Posteon capsules composition: Persea america, glycine max (Avocado soybean unsaponifiables (ASU)) [Extract ratio 1:2] 300mg, AprèsFlexTM (AprèsFlex is a registered trademark of PLT Health Solutions-Laila Nutraceuticals LLC) Boswellia serrata (Indian frankincense) powder extract (gum resin) 100 mg. Complementary Medicines: Discipline-Specific Traditional Claims D33.7 Combination product. This unregistered medicine has not been evaluated by SAHPRA for its quality, safety or intended use. Name and business address: iNova Pharmaceuticals (Pty) Ltd. Co. Reg. No. 1952/001640/07,15E Riley Road, Bedfordview. Tel. No. 011 087 0000. www.inovapharma.co.za. Further information is available on request from iNova Pharmaceuticals. For full prescribing information refer to the professional information available at www.inovapharma.co.za. IN2176/23